Neuroradiology and histopathology in two cases of adult medulloblastoma
Medulloblastoma (MB) is the most common central nervous system neoplasm in children and only rarely presents in the adult population. Recent molecular biology findings have characterized MB as a heterogeneous neoplasm distinguished by well-defined tumour subsets each with specific histologic and mol...
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2014
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Romero Rojas, Alfredo E. Diaz Perez, Julio A. Raju, Sharat Lozano Castillo, Alfonso 2019-08-09T17:02:09Z 2019-08-09T17:02:09Z 2014 6 p. Medulloblastoma (MB) is the most common central nervous system neoplasm in children and only rarely presents in the adult population. Recent molecular biology findings have characterized MB as a heterogeneous neoplasm distinguished by well-defined tumour subsets each with specific histologic and molecular features. Available immunohistochemical stains can now be used to differentiate the distinct molecular types of MB. This report analyzed the histopathologic and neuroradiologic features of two new cases of adult MB. Imaging studies in these patients revealed the morphological appearance of high-grade, well-circumscribed heterogeneous tumours with necrosis, located laterally within the posterior cranial fossa. Histopathology of resected samples demonstrated high-grade tumours (WHO grade IV) containing sheets of undifferentiated neural cells with high mitotic activity and evidence of necrosis. The histopathologic and molecular characteristics of these cases of MB are reviewed for potential applications in new molecular methods of imaging. application/pdf 10.15274/NRJ-2014-10021 2385-1996 1971-4009 https://repositorio.udes.edu.co/handle/001/3564 eng Neuroradiology Journal Derechos Reservados - Universidad de Santander, 2014 info:eu-repo/semantics/openAccess Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202854/pdf/NRJ-27-163.pdf Medulloblastoma Adult patients Neuroradiology Histopathology Immunohistochemistry Molecular imaging Neuroradiology and histopathology in two cases of adult medulloblastoma Artículo de revista http://purl.org/coar/resource_type/c_6501 Text info:eu-repo/semantics/article http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion Publication http://purl.org/coar/access_right/c_abf2 http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| institution |
Universidad EIA |
| collection |
d_repositorio.udes.edu.co-DSPACE |
| title |
Neuroradiology and histopathology in two cases of adult medulloblastoma |
| spellingShingle |
Neuroradiology and histopathology in two cases of adult medulloblastoma Romero Rojas, Alfredo E. Diaz Perez, Julio A. Raju, Sharat Lozano Castillo, Alfonso Romero Rojas, Alfredo E. Diaz Perez, Julio A. Raju, Sharat Lozano Castillo, Alfonso Medulloblastoma Adult patients Neuroradiology Histopathology Immunohistochemistry Molecular imaging |
| title_short |
Neuroradiology and histopathology in two cases of adult medulloblastoma |
| title_full |
Neuroradiology and histopathology in two cases of adult medulloblastoma |
| title_fullStr |
Neuroradiology and histopathology in two cases of adult medulloblastoma |
| title_full_unstemmed |
Neuroradiology and histopathology in two cases of adult medulloblastoma |
| title_sort |
neuroradiology and histopathology in two cases of adult medulloblastoma |
| author |
Romero Rojas, Alfredo E. Diaz Perez, Julio A. Raju, Sharat Lozano Castillo, Alfonso Romero Rojas, Alfredo E. Diaz Perez, Julio A. Raju, Sharat Lozano Castillo, Alfonso |
| author_facet |
Romero Rojas, Alfredo E. Diaz Perez, Julio A. Raju, Sharat Lozano Castillo, Alfonso Romero Rojas, Alfredo E. Diaz Perez, Julio A. Raju, Sharat Lozano Castillo, Alfonso |
| building |
Repositorio digital |
| topic |
Medulloblastoma Adult patients Neuroradiology Histopathology Immunohistochemistry Molecular imaging |
| topic_facet |
Medulloblastoma Adult patients Neuroradiology Histopathology Immunohistochemistry Molecular imaging |
| publishDate |
2014 |
| language |
English |
| format |
Artículo de revista |
| description |
Medulloblastoma (MB) is the most common central nervous system neoplasm in children and only rarely presents in the adult population. Recent molecular biology findings have characterized MB as a heterogeneous neoplasm distinguished by well-defined tumour subsets each with specific histologic and molecular features. Available immunohistochemical stains can now be used to differentiate the distinct molecular types of MB. This report analyzed the histopathologic and neuroradiologic features of two new cases of adult MB. Imaging studies in these patients revealed the morphological appearance of high-grade, well-circumscribed heterogeneous tumours with necrosis, located laterally within the posterior cranial fossa. Histopathology of resected samples demonstrated high-grade tumours (WHO grade IV) containing sheets of undifferentiated neural cells with high mitotic activity and evidence of necrosis. The histopathologic and molecular characteristics of these cases of MB are reviewed for potential applications in new molecular methods of imaging.
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| issn |
2385-1996 |
| url |
https://repositorio.udes.edu.co/handle/001/3564 |
| url_str_mv |
https://repositorio.udes.edu.co/handle/001/3564 |
| _version_ |
1789502187486838784 |
| score |
11.25946 |
