Periodontal disease severity is related to high levels of C-reactive protein in pre-eclampsia
Objective Recent studies have shown that pre-eclamptic women present a high prevalence of periodontitis, suggesting that active periodontal disease may play a role in the pathogenesis of pre-eclampsia. The present study analysed the effect of periodontal disease in the concentrations of serum high-...
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2007-07
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Herrera, Julián A. Parra, Beatriz Herrera, Enrique Botero, Javier E. Arce, Roger M. Contreras, Adolfo Lopez-Jaramillo, Patricio 2019-08-29T17:17:56Z 2019-08-29T17:17:56Z 2007-07 6 p. Objective Recent studies have shown that pre-eclamptic women present a high prevalence of periodontitis, suggesting that active periodontal disease may play a role in the pathogenesis of pre-eclampsia. The present study analysed the effect of periodontal disease in the concentrations of serum high-sensitivity C-reactive protein (hs-CRP), and its association with pre-eclampsia. Methods A case–control study was carried out in Cali-Colombia, comprised of 398 pregnant women (145 cases and 253 controls) who were believed to have periodontal disease, between 28 and 36 weeks of gestational age. Pre-eclampsia cases were defined as blood pressure >– 140/90 mmHg and proteinuria >– 0.3 g/24 h. Controls were pregnant women with normal blood pressure, without proteinuria, matched by maternal age, gestational age and body mass index. Sociodemographic data, obstetric risk factors, periodontal state, subgingival microbial composition and hs-CRP levels were determined in both groups. Results The case and control groups were comparable for sociodemographic characteristics. In women with pre-eclampsia and confirmed periodontal disease (n U 138), hs-CRP levels increased according to the severity of the disease (gingivitis median 4.14 mg/dl; mild periodontitis median 4.70 mg/dl; moderate/severe periodontitis median 8.8 mg/dl; P U 0.01). A similar tendency was observed in controls with periodontal disease (n U 251), but it did not reach statistical significance (gingivitis median 5.10 mg/dl; mild periodontitis median 5.12 mg/dl; moderate/severe periodontitis median 6.90 mg/dl; P U 0.07). A significant difference in hs-CRP levels was observed in pre-eclamptic women with moderate/severe periodontitis compared to controls (P U 0.01). Conclusion These findings suggest that chronic periodontitis may increase hs-CRP levels in pregnant women and lead to complications such as pre-eclampsia. application/pdf 10.1097/HJH.0b013e3281139ea9 1473-5598 0263-6352 https://repositorio.udes.edu.co/handle/001/3692 eng Journal of Hypertension Journal of Hypertension;Vol. 25 (7), pp. 1459-1464. 2007 Derechos Reservados - Journal of Hypertension, 2007 info:eu-repo/semantics/openAccess Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/ https://journals.lww.com/jhypertension/fulltext/2007/07000/Periodontal_disease_severity_is_related_to_high.23.aspx#pdf-link Bacterial infection Chronic periodontitis C-reactive protein Preeclampsia Periodontal disease severity is related to high levels of C-reactive protein in pre-eclampsia Artículo de revista http://purl.org/coar/resource_type/c_6501 Text info:eu-repo/semantics/article http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion Publication http://purl.org/coar/access_right/c_abf2 http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| institution |
Universidad EIA |
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d_repositorio.udes.edu.co-DSPACE |
| title |
Periodontal disease severity is related to high levels of C-reactive protein in pre-eclampsia |
| spellingShingle |
Periodontal disease severity is related to high levels of C-reactive protein in pre-eclampsia Herrera, Julián A. Parra, Beatriz Herrera, Enrique Botero, Javier E. Arce, Roger M. Contreras, Adolfo Lopez-Jaramillo, Patricio Herrera, Julián A. Parra, Beatriz Herrera, Enrique Botero, Javier E. Arce, Roger M. Contreras, Adolfo Lopez-Jaramillo, Patricio Bacterial infection Chronic periodontitis C-reactive protein Preeclampsia |
| title_short |
Periodontal disease severity is related to high levels of C-reactive protein in pre-eclampsia |
| title_full |
Periodontal disease severity is related to high levels of C-reactive protein in pre-eclampsia |
| title_fullStr |
Periodontal disease severity is related to high levels of C-reactive protein in pre-eclampsia |
| title_full_unstemmed |
Periodontal disease severity is related to high levels of C-reactive protein in pre-eclampsia |
| title_sort |
periodontal disease severity is related to high levels of c-reactive protein in pre-eclampsia |
| author |
Herrera, Julián A. Parra, Beatriz Herrera, Enrique Botero, Javier E. Arce, Roger M. Contreras, Adolfo Lopez-Jaramillo, Patricio Herrera, Julián A. Parra, Beatriz Herrera, Enrique Botero, Javier E. Arce, Roger M. Contreras, Adolfo Lopez-Jaramillo, Patricio |
| author_facet |
Herrera, Julián A. Parra, Beatriz Herrera, Enrique Botero, Javier E. Arce, Roger M. Contreras, Adolfo Lopez-Jaramillo, Patricio Herrera, Julián A. Parra, Beatriz Herrera, Enrique Botero, Javier E. Arce, Roger M. Contreras, Adolfo Lopez-Jaramillo, Patricio |
| building |
Repositorio digital |
| topic |
Bacterial infection Chronic periodontitis C-reactive protein Preeclampsia |
| topic_facet |
Bacterial infection Chronic periodontitis C-reactive protein Preeclampsia |
| publishDate |
2007-07 |
| language |
English |
| format |
Artículo de revista |
| description |
Objective Recent studies have shown that pre-eclamptic women present a high prevalence of periodontitis,
suggesting that active periodontal disease may play a role in the pathogenesis of pre-eclampsia. The present study analysed the effect of periodontal disease in the concentrations of serum high-sensitivity C-reactive protein (hs-CRP), and its association with pre-eclampsia. Methods A case–control study was carried out in
Cali-Colombia, comprised of 398 pregnant women (145 cases and 253 controls) who were believed to have
periodontal disease, between 28 and 36 weeks of gestational age. Pre-eclampsia cases were defined as blood
pressure >– 140/90 mmHg and proteinuria >– 0.3 g/24 h. Controls were pregnant women with normal blood pressure, without proteinuria, matched by maternal age, gestational age and body mass index. Sociodemographic data, obstetric risk factors, periodontal state, subgingival microbial composition and hs-CRP levels were determined in both groups. Results The case and control groups were comparable for sociodemographic characteristics. In women with pre-eclampsia and confirmed periodontal disease (n U 138), hs-CRP levels increased according to the severity of the disease (gingivitis median 4.14 mg/dl; mild
periodontitis median 4.70 mg/dl; moderate/severe periodontitis median 8.8 mg/dl; P U 0.01). A similar
tendency was observed in controls with periodontal disease (n U 251), but it did not reach statistical significance (gingivitis median 5.10 mg/dl; mild periodontitis median 5.12 mg/dl; moderate/severe periodontitis median 6.90 mg/dl; P U 0.07). A significant difference in hs-CRP levels was observed in pre-eclamptic women with moderate/severe periodontitis compared to controls (P U 0.01).
Conclusion These findings suggest that chronic periodontitis may increase hs-CRP levels in pregnant
women and lead to complications such as pre-eclampsia.
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| issn |
1473-5598 |
| url |
https://repositorio.udes.edu.co/handle/001/3692 |
| url_str_mv |
https://repositorio.udes.edu.co/handle/001/3692 |
| _version_ |
1789502056048885760 |
| score |
11.346045 |
