Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in prospective urban and rural epidemiology study
Objective. To evaluate the association between intakes of refined grains, whole grains, and white rice with cardiovascular disease, total mortality, blood lipids, and blood pressure in the Prospective Urban and Rural Epidemiology (PURE) study. Design. Prospective cohort study. Setting PURE study in...
Saved in:
| Institution: | Universidad EIA |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artículo de revista |
| Language: | English |
| Published: |
BMJ
2021-02-03
|
| Online Access: | https://repositorio.udes.edu.co/handle/001/6031 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
oai:null:001-6031 |
|---|---|
| recordtype |
dspace |
| spelling |
Dehghan, Mahshid Raj, John Michael Thomas, Tinku Rangarajan, Sumathy Jenkins, David Mony, Prem Mohan, Viswanathan Lear, Scott A. Avezum, Alvaro Lopez-Jaramillo, Patricio Rosengren, Annika Lanas, Fernando AlHabib, Khalid F. Dans, Antonio Keskinler, Mirac Vural Puoane, Thandi Soman, Biju Wei, Li Zatonska, Katarzyna Diaz, Rafael Ismail, Noorhassim Chifamba, Jephat Kelishadi, Roya Yusufali, Afzalhussein Khatib, Rasha Xiaoyun, Liu Bo, Hu Iqbal, Romaina Yusuf, Rita Yeates, Karen Teo, Koon Yusuf, Salim Masira 2022-02-17T15:58:44Z 2022-02-17T15:58:44Z 2021-02-03 Digital Objective. To evaluate the association between intakes of refined grains, whole grains, and white rice with cardiovascular disease, total mortality, blood lipids, and blood pressure in the Prospective Urban and Rural Epidemiology (PURE) study. Design. Prospective cohort study. Setting PURE study in 21 countries. Participants 148858 participants with median follow-up of 9.5 years. Exposures Country specific validated food frequency questionnaires were used to assess intakes of refined grains, whole grains, and white rice. Main outcome measure Composite of mortality or major cardiovascular events (defined as death from cardiovascular causes, nonfatal myocardial infarction, stroke, or heart failure). Hazard ratios were estimated for associations of grain intakes with mortality, major cardiovascular events, and their composite by using multivariable Cox frailty models with random intercepts to account for clustering by centre. Results Analyses were based on 137130 participants after exclusion of those with baseline cardiovascular disease. During follow-up, 9.2% (n=12668) of these participants had a composite outcome event. The highest category of intake of refined grains (≥350 g/day or about 7 servings/day) was associated with higher risk of total mortality (hazard ratio 1.27, 95% confidence interval 1.11 to 1.46; P for trend=0.004), major cardiovascular disease events (1.33, 1.16 to 1.52; P for trend<0.001), and their composite (1.28, 1.15 to 1.42; P for trend<0.001) compared with the lowest category of intake (<50 g/day). Higher intakes of refined grains were associated with higher systolic blood pressure. No significant associations were found between intakes of whole grains or white rice and health outcomes. Conclusion High intake of refined grains was associated with higher risk of mortality and major cardiovascular disease events. Globally, lower consumption of refined grains should be considered. Ciencias Médicas y de la Salud 16 p application/pdf http://dx.doi.org/10.1136/bmj.m4948 https://repositorio.udes.edu.co/handle/001/6031 eng BMJ Reino Unido 16 4948 1 BMJ 2021;372:m4948 Scopus The BMJ Copyrights The Authors, BMJ, 2021 info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/ https://www.bmj.com/content/bmj/372/bmj.m4948.full.pdf Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in prospective urban and rural epidemiology study Prospective cohort study Artículo de revista http://purl.org/coar/resource_type/c_6501 Text info:eu-repo/semantics/article http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion Todas las Audiencias Publication http://purl.org/coar/access_right/c_abf2 http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| institution |
Universidad EIA |
| collection |
d_repositorio.udes.edu.co-DSPACE |
| title |
Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in prospective urban and rural epidemiology study |
| spellingShingle |
Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in prospective urban and rural epidemiology study Dehghan, Mahshid Raj, John Michael Thomas, Tinku Rangarajan, Sumathy Jenkins, David Mony, Prem Mohan, Viswanathan Lear, Scott A. Avezum, Alvaro Lopez-Jaramillo, Patricio Rosengren, Annika Lanas, Fernando AlHabib, Khalid F. Dans, Antonio Keskinler, Mirac Vural Puoane, Thandi Soman, Biju Wei, Li Zatonska, Katarzyna Diaz, Rafael Ismail, Noorhassim Chifamba, Jephat Kelishadi, Roya Yusufali, Afzalhussein Khatib, Rasha Xiaoyun, Liu Bo, Hu Iqbal, Romaina Yusuf, Rita Yeates, Karen Teo, Koon Yusuf, Salim Dehghan, Mahshid Raj, John Michael Thomas, Tinku Rangarajan, Sumathy Jenkins, David Mony, Prem Mohan, Viswanathan Lear, Scott A. Avezum, Alvaro Lopez-Jaramillo, Patricio Rosengren, Annika Lanas, Fernando AlHabib, Khalid F. Dans, Antonio Keskinler, Mirac Vural Puoane, Thandi Soman, Biju Wei, Li Zatonska, Katarzyna Diaz, Rafael Ismail, Noorhassim Chifamba, Jephat Kelishadi, Roya Yusufali, Afzalhussein Khatib, Rasha Xiaoyun, Liu Bo, Hu Iqbal, Romaina Yusuf, Rita Yeates, Karen Teo, Koon Yusuf, Salim Masira |
| title_short |
Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in prospective urban and rural epidemiology study |
| title_full |
Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in prospective urban and rural epidemiology study |
| title_fullStr |
Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in prospective urban and rural epidemiology study |
| title_full_unstemmed |
Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in prospective urban and rural epidemiology study |
| title_sort |
associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in prospective urban and rural epidemiology study |
| author |
Dehghan, Mahshid Raj, John Michael Thomas, Tinku Rangarajan, Sumathy Jenkins, David Mony, Prem Mohan, Viswanathan Lear, Scott A. Avezum, Alvaro Lopez-Jaramillo, Patricio Rosengren, Annika Lanas, Fernando AlHabib, Khalid F. Dans, Antonio Keskinler, Mirac Vural Puoane, Thandi Soman, Biju Wei, Li Zatonska, Katarzyna Diaz, Rafael Ismail, Noorhassim Chifamba, Jephat Kelishadi, Roya Yusufali, Afzalhussein Khatib, Rasha Xiaoyun, Liu Bo, Hu Iqbal, Romaina Yusuf, Rita Yeates, Karen Teo, Koon Yusuf, Salim Dehghan, Mahshid Raj, John Michael Thomas, Tinku Rangarajan, Sumathy Jenkins, David Mony, Prem Mohan, Viswanathan Lear, Scott A. Avezum, Alvaro Lopez-Jaramillo, Patricio Rosengren, Annika Lanas, Fernando AlHabib, Khalid F. Dans, Antonio Keskinler, Mirac Vural Puoane, Thandi Soman, Biju Wei, Li Zatonska, Katarzyna Diaz, Rafael Ismail, Noorhassim Chifamba, Jephat Kelishadi, Roya Yusufali, Afzalhussein Khatib, Rasha Xiaoyun, Liu Bo, Hu Iqbal, Romaina Yusuf, Rita Yeates, Karen Teo, Koon Yusuf, Salim Masira |
| author_facet |
Dehghan, Mahshid Raj, John Michael Thomas, Tinku Rangarajan, Sumathy Jenkins, David Mony, Prem Mohan, Viswanathan Lear, Scott A. Avezum, Alvaro Lopez-Jaramillo, Patricio Rosengren, Annika Lanas, Fernando AlHabib, Khalid F. Dans, Antonio Keskinler, Mirac Vural Puoane, Thandi Soman, Biju Wei, Li Zatonska, Katarzyna Diaz, Rafael Ismail, Noorhassim Chifamba, Jephat Kelishadi, Roya Yusufali, Afzalhussein Khatib, Rasha Xiaoyun, Liu Bo, Hu Iqbal, Romaina Yusuf, Rita Yeates, Karen Teo, Koon Yusuf, Salim Dehghan, Mahshid Raj, John Michael Thomas, Tinku Rangarajan, Sumathy Jenkins, David Mony, Prem Mohan, Viswanathan Lear, Scott A. Avezum, Alvaro Lopez-Jaramillo, Patricio Rosengren, Annika Lanas, Fernando AlHabib, Khalid F. Dans, Antonio Keskinler, Mirac Vural Puoane, Thandi Soman, Biju Wei, Li Zatonska, Katarzyna Diaz, Rafael Ismail, Noorhassim Chifamba, Jephat Kelishadi, Roya Yusufali, Afzalhussein Khatib, Rasha Xiaoyun, Liu Bo, Hu Iqbal, Romaina Yusuf, Rita Yeates, Karen Teo, Koon Yusuf, Salim Masira |
| building |
Repositorio digital |
| publishDate |
2021-02-03 |
| language |
English |
| publisher |
BMJ |
| physical |
16 p |
| format |
Artículo de revista |
| title_alt |
Prospective cohort study |
| description |
Objective. To evaluate the association between intakes of refined grains, whole grains, and white rice with cardiovascular disease, total mortality, blood lipids, and blood pressure in the Prospective Urban and Rural Epidemiology (PURE) study.
Design. Prospective cohort study. Setting PURE study in 21 countries.
Participants 148858 participants with median follow-up of 9.5 years.
Exposures Country specific validated food frequency questionnaires were used to assess intakes of refined grains, whole grains, and white rice.
Main outcome measure Composite of mortality or major cardiovascular events
(defined as death from cardiovascular causes, nonfatal myocardial infarction, stroke, or heart failure).
Hazard ratios were estimated for associations of grain intakes with mortality, major cardiovascular events, and their composite by using multivariable Cox frailty models with random intercepts to account for clustering by centre.
Results Analyses were based on 137130 participants after exclusion of those with baseline cardiovascular disease. During follow-up, 9.2% (n=12668) of these
participants had a composite outcome event. The highest category of intake of refined grains (≥350 g/day or about 7 servings/day) was associated with higher risk of total mortality (hazard ratio 1.27, 95% confidence interval 1.11 to 1.46; P for trend=0.004),
major cardiovascular disease events (1.33, 1.16 to 1.52; P for trend<0.001), and their composite (1.28, 1.15 to 1.42; P for trend<0.001) compared with the lowest category of intake (<50 g/day). Higher intakes of refined grains were associated with higher systolic blood pressure. No significant associations were found between intakes of whole grains or white rice and health outcomes.
Conclusion High intake of refined grains was associated with higher risk of mortality and major cardiovascular disease events. Globally, lower consumption of refined grains should be considered.
|
| url |
https://repositorio.udes.edu.co/handle/001/6031 |
| url_str_mv |
https://repositorio.udes.edu.co/handle/001/6031 |
| _version_ |
1789502038729555968 |
| score |
11.257267 |
