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Obesity and Preeclampsia. Common Pathophysiological Mechanisms

Preeclampsia is a disorder specific of the human being that appears after 20 weeks of pregnancy, characterized by new onset of hypertension and proteinuria. Abnormal placentation and reduced placental perfusion associated to impaired trophoblast invasion and alteration in the compliance of uterin...

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Institution:Universidad EIA
Main Authors: Lopez-Jaramillo, Patricio, Barajas, Juan, Rueda-Quijano, Sandra M., Lopez-Lopez, Cristina, Felix, Camilo, Masira
Format: Artículo de revista
Language:English
Published: Frontiers in Physiology 2018-12-19
Subjects:
Preeclampsia
Obesity
Endothelial dysfunction
Nitric oxide
Cardiovascular risk
Online Access:https://repositorio.udes.edu.co/handle/001/6094
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recordtype dspace
spelling Lopez-Jaramillo, Patricio
Barajas, Juan
Rueda-Quijano, Sandra M.
Lopez-Lopez, Cristina
Felix, Camilo
Masira
2022-02-22T13:26:03Z
2022-02-22T13:26:03Z
2018-12-19
Digital
Preeclampsia is a disorder specific of the human being that appears after 20 weeks of pregnancy, characterized by new onset of hypertension and proteinuria. Abnormal placentation and reduced placental perfusion associated to impaired trophoblast invasion and alteration in the compliance of uterine spiral arteries are the early pathological findings that are present before the clinical manifestations of preeclampsia. Later on, the endothelial and vascular dysfunction responsible of the characteristic vasoconstriction of preeclampsia appear. Different nutritional risk factors such as a maternal deficit in the intake of calcium, protein, vitamins and essential fatty acids, have been shown to play a role in the genesis of preeclampsia, but also an excess of weight gain during pregnancy or a pre-pregnancy state of obesity and overweight, which are associated to hyperinsulinism, insulin resistance and maternal systemic inflammation, are proposed as one of the mechanism that conduce to endothelial dysfunction, hypertension, proteinuria, thrombotic responses, multi-organ damage, and high maternal mortality and morbidity. Moreover, it has been demonstrated that pregnant women that suffer preeclampsia will have an increased risk of future cardiovascular disease and related mortality in their later life. In this article we will discuss the results of studies performed in different populations that have shown an interrelationship between obesity and overweight with the presence of preeclampsia. Moreover, we will review some of the common mechanisms that explain this interrelationship, particularly the alterations in the L-arginine/nitric oxide pathway as a crucial mechanism that is common to obesity, preeclampsia and cardiovascular diseases.
Ciencias Médicas y de la Salud
10 p
application/pdf
10.3389/fphys.2018.01838
https://repositorio.udes.edu.co/handle/001/6094
eng
Frontiers in Physiology
USA
10
1
9
Lopez-Jaramillo P, Barajas J, Rueda-Quijano SM, Lopez-Lopez C and Felix C (2018) Obesity and Preeclampsia: Common Pathophysiological Mechanisms. Front. Physiol. 9:1838. doi: 10.3389/fphys.2018.01838
Scopus
Frontiers in Physiology
© 2018 Lopez-Jaramillo, Barajas, Rueda-Quijano, Lopez-Lopez and Felix.
info:eu-repo/semantics/openAccess
Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
https://creativecommons.org/licenses/by-nc/4.0/
https://www.frontiersin.org/articles/10.3389/fphys.2018.01838/full
Preeclampsia
Obesity
Endothelial dysfunction
Nitric oxide
Cardiovascular risk
Obesity and Preeclampsia. Common Pathophysiological Mechanisms
Artículo de revista
http://purl.org/coar/resource_type/c_6501
Text
info:eu-repo/semantics/article
http://purl.org/redcol/resource_type/ART
info:eu-repo/semantics/publishedVersion
Todas las Audiencias
Publication
http://purl.org/coar/access_right/c_abf2
http://purl.org/coar/version/c_970fb48d4fbd8a85
institution Universidad EIA
collection d_repositorio.udes.edu.co-DSPACE
title Obesity and Preeclampsia. Common Pathophysiological Mechanisms
spellingShingle Obesity and Preeclampsia. Common Pathophysiological Mechanisms
Lopez-Jaramillo, Patricio
Barajas, Juan
Rueda-Quijano, Sandra M.
Lopez-Lopez, Cristina
Felix, Camilo
Lopez-Jaramillo, Patricio
Barajas, Juan
Rueda-Quijano, Sandra M.
Lopez-Lopez, Cristina
Felix, Camilo
Masira
Preeclampsia
Obesity
Endothelial dysfunction
Nitric oxide
Cardiovascular risk
title_short Obesity and Preeclampsia. Common Pathophysiological Mechanisms
title_full Obesity and Preeclampsia. Common Pathophysiological Mechanisms
title_fullStr Obesity and Preeclampsia. Common Pathophysiological Mechanisms
title_full_unstemmed Obesity and Preeclampsia. Common Pathophysiological Mechanisms
title_sort obesity and preeclampsia. common pathophysiological mechanisms
author Lopez-Jaramillo, Patricio
Barajas, Juan
Rueda-Quijano, Sandra M.
Lopez-Lopez, Cristina
Felix, Camilo
Lopez-Jaramillo, Patricio
Barajas, Juan
Rueda-Quijano, Sandra M.
Lopez-Lopez, Cristina
Felix, Camilo
Masira
author_facet Lopez-Jaramillo, Patricio
Barajas, Juan
Rueda-Quijano, Sandra M.
Lopez-Lopez, Cristina
Felix, Camilo
Lopez-Jaramillo, Patricio
Barajas, Juan
Rueda-Quijano, Sandra M.
Lopez-Lopez, Cristina
Felix, Camilo
Masira
building Repositorio digital
topic Preeclampsia
Obesity
Endothelial dysfunction
Nitric oxide
Cardiovascular risk
topic_facet Preeclampsia
Obesity
Endothelial dysfunction
Nitric oxide
Cardiovascular risk
publishDate 2018-12-19
language English
publisher Frontiers in Physiology
physical 10 p
format Artículo de revista
description Preeclampsia is a disorder specific of the human being that appears after 20 weeks of pregnancy, characterized by new onset of hypertension and proteinuria. Abnormal placentation and reduced placental perfusion associated to impaired trophoblast invasion and alteration in the compliance of uterine spiral arteries are the early pathological findings that are present before the clinical manifestations of preeclampsia. Later on, the endothelial and vascular dysfunction responsible of the characteristic vasoconstriction of preeclampsia appear. Different nutritional risk factors such as a maternal deficit in the intake of calcium, protein, vitamins and essential fatty acids, have been shown to play a role in the genesis of preeclampsia, but also an excess of weight gain during pregnancy or a pre-pregnancy state of obesity and overweight, which are associated to hyperinsulinism, insulin resistance and maternal systemic inflammation, are proposed as one of the mechanism that conduce to endothelial dysfunction, hypertension, proteinuria, thrombotic responses, multi-organ damage, and high maternal mortality and morbidity. Moreover, it has been demonstrated that pregnant women that suffer preeclampsia will have an increased risk of future cardiovascular disease and related mortality in their later life. In this article we will discuss the results of studies performed in different populations that have shown an interrelationship between obesity and overweight with the presence of preeclampsia. Moreover, we will review some of the common mechanisms that explain this interrelationship, particularly the alterations in the L-arginine/nitric oxide pathway as a crucial mechanism that is common to obesity, preeclampsia and cardiovascular diseases.
url https://repositorio.udes.edu.co/handle/001/6094
url_str_mv https://repositorio.udes.edu.co/handle/001/6094
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