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Development of Envelope Protein Antigens To Serologically Differentiate Zika Virus Infection from Dengue Virus Infection

Zika virus (ZIKV) is an emerging flavivirus that can cause birth defects and neurologic complications. Molecular tests are effective for diagnosing acute ZIKV infection, although the majority of infections produce no symptoms at all or present after the narrow window in which molecular diagnostics a...

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Bibliographic Details
Institution:Universidad de Sucre
Main Authors: Lakshmanane, Premkumar, Collins, Matthew, Graham, Stephen, Liou, Guei-Jiun Alice, Camacho, Erwin
Format: Artículo de revista
Language:English
Published: Estados Unidos: Journal of Clinical Microbiology,2018. 2019-09-19
Subjects:
Comparative epitope mapping
Computational prediction
ELISA
Zika virus
Antibody-binding region
Cross-reactivity
Dengue virus
Flavivirus
Serological diagnosis
Surveillance
Online Access:https://repositorio.unisucre.edu.co/handle/001/776
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Summary:Zika virus (ZIKV) is an emerging flavivirus that can cause birth defects and neurologic complications. Molecular tests are effective for diagnosing acute ZIKV infection, although the majority of infections produce no symptoms at all or present after the narrow window in which molecular diagnostics are dependable. Serology is a reliable method for detecting infections after the viremic period; however, most serological assays have limited specificity due to cross-reactive antibodies elicited by flavivirus infections. Since ZIKV and dengue virus (DENV) widely cocirculate, distinguishing ZIKV infection from DENV infection is particularly important for diagnosing individual cases or for surveillance to coordinate public health responses.
ISSN:0095-1137