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Cutaneous Perivascular Epithelioid Cell Tumor of Gynecologic Origin Metastatic to Skin, Lung, Stomach, and Brain

Regarding the first case report recently published by Navale et al1 about a skin perivascular epithelioid cell tumor (PEComa) with focal melanin pigmentation, we wish to present another exceptional case of a malignant uterine PEComa metastatic to skin and lung, gastric lymph-vascular invasion, and b...

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Institution:FUCS -Fundación Universitaria de Ciencias de la Salud
Main Authors: Parra Medina, Rafael, Morales, Samuel D.
Format: Artículo de revista
Language:English
Published: Wolters Kluwer Health 2017
Subjects:
Células epitelioides
Cerebro
Estómago
Pulmón
Piel
Online Access:https://repositorio.fucsalud.edu.co/handle/001/1693
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id oai:repositorio.fucsalud.edu.co:001-1693
recordtype dspace
spelling Parra Medina, Rafael
Morales, Samuel D.
2021-08-05T16:49:14Z
2017
2021-08-05T16:49:14Z
Wolters Kluwer Health
Estados Unidos
Regarding the first case report recently published by Navale et al1 about a skin perivascular epithelioid cell tumor (PEComa) with focal melanin pigmentation, we wish to present another exceptional case of a malignant uterine PEComa metastatic to skin and lung, gastric lymph-vascular invasion, and brain dissemination, which was also initially misdiagnosed as skin melanoma because of the presence of epithelioid features and the expression of some melanocytic markers. Our patient was a 62-year-old woman, who presented with abnormal uterine bleeding that prompted hysterectomy 3 years ago. An extrainstitutional pathology report on the surgical specimen revealed a lesion compatible with a uterine leiomyosarcoma that was managed with adjuvant radiotherapy. At the 2-year clinical follow-up, the patient presented with a mass on the posterior region of the neck, which required undergoing surgical excision. The pathology study features were compatible with a malignant melanoma. Other reassessment and follow-up studies evidenced a compromise of the lung, with histopathological diagnosis of metastatic melanoma. A year ago, the patient presented with a new pigmented lesion on the right cheek. Once again, the biopsy study revealed a melanoma.
https://journals.lww.com/amjdermatopathology/Fulltext/2017/02000/Cutaneous_Perivascular_Epithelioid_Cell_Tumor_of.17.aspx
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Cutaneous Perivascular Epithelioid Cell Tumor of Gynecologic Origin Metastatic to Skin, Lung, Stomach, and Brain
Artículo de revista
http://purl.org/coar/resource_type/c_6501
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Text
https://purl.org/redcol/resource_type/WP
http://purl.org/coar/version/c_970fb48d4fbd8a85
https://repositorio.fucsalud.edu.co/handle/001/1693
eng
The American Journal of dermatopathology eISSN:1533-031 Vol.39 Núm.2 (2017)
159
2
157
39
The American Journal of dermatopathology
info:eu-repo/semantics/openAccess
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
https://creativecommons.org/licenses/by-nd/4.0/
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Células epitelioides
Cerebro
Estómago
Pulmón
Piel
Publication
institution FUCS -Fundación Universitaria de Ciencias de la Salud
collection d_repositorio.fucsalud.edu.co-DSPACE
title Cutaneous Perivascular Epithelioid Cell Tumor of Gynecologic Origin Metastatic to Skin, Lung, Stomach, and Brain
spellingShingle Cutaneous Perivascular Epithelioid Cell Tumor of Gynecologic Origin Metastatic to Skin, Lung, Stomach, and Brain
Parra Medina, Rafael
Morales, Samuel D.
Parra Medina, Rafael
Morales, Samuel D.
Células epitelioides
Cerebro
Estómago
Pulmón
Piel
title_short Cutaneous Perivascular Epithelioid Cell Tumor of Gynecologic Origin Metastatic to Skin, Lung, Stomach, and Brain
title_full Cutaneous Perivascular Epithelioid Cell Tumor of Gynecologic Origin Metastatic to Skin, Lung, Stomach, and Brain
title_fullStr Cutaneous Perivascular Epithelioid Cell Tumor of Gynecologic Origin Metastatic to Skin, Lung, Stomach, and Brain
title_full_unstemmed Cutaneous Perivascular Epithelioid Cell Tumor of Gynecologic Origin Metastatic to Skin, Lung, Stomach, and Brain
title_sort cutaneous perivascular epithelioid cell tumor of gynecologic origin metastatic to skin, lung, stomach, and brain
author Parra Medina, Rafael
Morales, Samuel D.
Parra Medina, Rafael
Morales, Samuel D.
author_facet Parra Medina, Rafael
Morales, Samuel D.
Parra Medina, Rafael
Morales, Samuel D.
building Repositorio digital
topic Células epitelioides
Cerebro
Estómago
Pulmón
Piel
topic_facet Células epitelioides
Cerebro
Estómago
Pulmón
Piel
publishDate 2017
language English
publisher Wolters Kluwer Health
physical 3 p.
format Artículo de revista
description Regarding the first case report recently published by Navale et al1 about a skin perivascular epithelioid cell tumor (PEComa) with focal melanin pigmentation, we wish to present another exceptional case of a malignant uterine PEComa metastatic to skin and lung, gastric lymph-vascular invasion, and brain dissemination, which was also initially misdiagnosed as skin melanoma because of the presence of epithelioid features and the expression of some melanocytic markers. Our patient was a 62-year-old woman, who presented with abnormal uterine bleeding that prompted hysterectomy 3 years ago. An extrainstitutional pathology report on the surgical specimen revealed a lesion compatible with a uterine leiomyosarcoma that was managed with adjuvant radiotherapy. At the 2-year clinical follow-up, the patient presented with a mass on the posterior region of the neck, which required undergoing surgical excision. The pathology study features were compatible with a malignant melanoma. Other reassessment and follow-up studies evidenced a compromise of the lung, with histopathological diagnosis of metastatic melanoma. A year ago, the patient presented with a new pigmented lesion on the right cheek. Once again, the biopsy study revealed a melanoma.
url https://repositorio.fucsalud.edu.co/handle/001/1693
url_str_mv https://repositorio.fucsalud.edu.co/handle/001/1693
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score 11.255725