The simultaneous assessment of glycosylated hemoglobin, fasting plasma glucose and oral glucose tolerance test does not improve the detection of type 2 diabetes mellitus in Colombian adults
Guidelines recommend early detection of type 2 diabetes mellitus (DM2). The objective of the present study was to evaluate the capacity to identify DM2 in subjects that were screened for DM2 simultaneously with all three of the tests recommended—fasting plasma glucose (FPG), glycosylated hemoglobin...
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Cohen, Daniel Dylan Lopez-Jaramillo, Patricio López López, Jose Garay, Jennifer Wandurraga, Edwin Camacho López, Paul Anthony Higuera Escalante, Fernando 2019-06-21T12:55:09Z 2019-06-21T12:55:09Z 2018-04-13 8 p. Guidelines recommend early detection of type 2 diabetes mellitus (DM2). The objective of the present study was to evaluate the capacity to identify DM2 in subjects that were screened for DM2 simultaneously with all three of the tests recommended—fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and a 2-hour post 75-g oral glucose tolerance test (OGTT). Methods and results The present analysis of an anonymous database of 1113 adults from a reference clinical laboratory in Bucaramanga, Colombia, was an observational, descriptive, cross-sectional secondary source study. 259 individuals met at least one of the criteria for DM2: FPG 126mg/dL (7.0mmol/L), HbA1c 6.5% (48mmol/mol) and OGTT 200mg/dL (11.1mmol/L). 30 subjects (2.7%) were diabetic according to FPG, 56 subjects (5.0%) by HbA1c and 250 subjects (22.5%) by OGTT. In total 259 subjects (23.3% [IC 95%: 20.7%– 25.8%] were diabetic either by FPG, OGTT or HbA1c. Discussion The largest number of patients were identified as diabetic with the OGTT. The combination of two or three tests did not increase the detection of new cases of DM2. Our findings suggest that routinely requesting FPG, OGTT and HbA1c at the same time may be inappropriate in at risk individuals, as this approach does not significantly improve the diagnostic capacity compared to using FPG+OGTT and substantially increases the financial burden on the health system, insurers or individual. application/pdf 10.1371/journal.pone.0194446 1932-620 https://repositorio.udes.edu.co/handle/001/3182 eng Revista Mexicana de Ciencias Pecuarias Derechos Reservados - Universidad de Santander, 2018 info:eu-repo/semantics/openAccess Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/ https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0194446&type=printable Glycosylated hemoglobin Type 2 diabetes mellitus The simultaneous assessment of glycosylated hemoglobin, fasting plasma glucose and oral glucose tolerance test does not improve the detection of type 2 diabetes mellitus in Colombian adults Artículo de revista http://purl.org/coar/resource_type/c_6501 Text info:eu-repo/semantics/article http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion Publication http://purl.org/coar/access_right/c_abf2 http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| institution |
Universidad EIA |
| collection |
d_repositorio.udes.edu.co-DSPACE |
| title |
The simultaneous assessment of glycosylated hemoglobin, fasting plasma glucose and oral glucose tolerance test does not improve the detection of type 2 diabetes mellitus in Colombian adults |
| spellingShingle |
The simultaneous assessment of glycosylated hemoglobin, fasting plasma glucose and oral glucose tolerance test does not improve the detection of type 2 diabetes mellitus in Colombian adults Cohen, Daniel Dylan Lopez-Jaramillo, Patricio López López, Jose Garay, Jennifer Wandurraga, Edwin Camacho López, Paul Anthony Higuera Escalante, Fernando Cohen, Daniel Dylan Lopez-Jaramillo, Patricio López López, Jose Garay, Jennifer Wandurraga, Edwin Camacho López, Paul Anthony Higuera Escalante, Fernando Glycosylated hemoglobin Type 2 diabetes mellitus |
| title_short |
The simultaneous assessment of glycosylated hemoglobin, fasting plasma glucose and oral glucose tolerance test does not improve the detection of type 2 diabetes mellitus in Colombian adults |
| title_full |
The simultaneous assessment of glycosylated hemoglobin, fasting plasma glucose and oral glucose tolerance test does not improve the detection of type 2 diabetes mellitus in Colombian adults |
| title_fullStr |
The simultaneous assessment of glycosylated hemoglobin, fasting plasma glucose and oral glucose tolerance test does not improve the detection of type 2 diabetes mellitus in Colombian adults |
| title_full_unstemmed |
The simultaneous assessment of glycosylated hemoglobin, fasting plasma glucose and oral glucose tolerance test does not improve the detection of type 2 diabetes mellitus in Colombian adults |
| title_sort |
simultaneous assessment of glycosylated hemoglobin, fasting plasma glucose and oral glucose tolerance test does not improve the detection of type 2 diabetes mellitus in colombian adults |
| author |
Cohen, Daniel Dylan Lopez-Jaramillo, Patricio López López, Jose Garay, Jennifer Wandurraga, Edwin Camacho López, Paul Anthony Higuera Escalante, Fernando Cohen, Daniel Dylan Lopez-Jaramillo, Patricio López López, Jose Garay, Jennifer Wandurraga, Edwin Camacho López, Paul Anthony Higuera Escalante, Fernando |
| author_facet |
Cohen, Daniel Dylan Lopez-Jaramillo, Patricio López López, Jose Garay, Jennifer Wandurraga, Edwin Camacho López, Paul Anthony Higuera Escalante, Fernando Cohen, Daniel Dylan Lopez-Jaramillo, Patricio López López, Jose Garay, Jennifer Wandurraga, Edwin Camacho López, Paul Anthony Higuera Escalante, Fernando |
| building |
Repositorio digital |
| topic |
Glycosylated hemoglobin Type 2 diabetes mellitus |
| topic_facet |
Glycosylated hemoglobin Type 2 diabetes mellitus |
| publishDate |
2018-04-13 |
| language |
English |
| format |
Artículo de revista |
| description |
Guidelines recommend early detection of type 2 diabetes mellitus (DM2). The objective of the present study was to evaluate the capacity to identify DM2 in subjects that were screened for DM2 simultaneously with all three of the tests recommended—fasting plasma glucose (FPG),
glycosylated hemoglobin (HbA1c) and a 2-hour post 75-g oral glucose tolerance test (OGTT).
Methods and results The present analysis of an anonymous database of 1113 adults from a reference clinical laboratory in Bucaramanga, Colombia, was an observational, descriptive, cross-sectional
secondary source study. 259 individuals met at least one of the criteria for DM2: FPG 126mg/dL (7.0mmol/L), HbA1c 6.5% (48mmol/mol) and OGTT 200mg/dL (11.1mmol/L). 30 subjects (2.7%) were diabetic according to FPG, 56 subjects (5.0%) by HbA1c and 250 subjects (22.5%) by OGTT. In total 259 subjects (23.3% [IC 95%: 20.7%– 25.8%] were diabetic either by FPG, OGTT or HbA1c.
Discussion
The largest number of patients were identified as diabetic with the OGTT. The combination of two or three tests did not increase the detection of new cases of DM2. Our findings suggest that routinely requesting FPG, OGTT and HbA1c at the same time may be inappropriate in at risk individuals, as this approach does not significantly improve the diagnostic capacity compared to using FPG+OGTT and substantially increases the financial burden on the health system, insurers or individual.
|
| issn |
1932-620 |
| url |
https://repositorio.udes.edu.co/handle/001/3182 |
| url_str_mv |
https://repositorio.udes.edu.co/handle/001/3182 |
| _version_ |
1763138299216527360 |
| score |
11.2563715 |
