Association of urinary sodium excretion with blood pressure and cardiovascular clinical events in 17,033 Latin americans
BACKGROUND: Information on actual sodium intake and its relationships with blood pressure (BP) and clinical events in South America is limited. The aim of this cohort study was to assess the relationship of sodium intake with BP, cardiovascular (CV) events, and mortality in South America. METHODS...
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Lamelas, Pablo M. Mente, Andrew Diaz, Rafael Orlandini, Andres Avezum, Alvaro Oliveira, Gustavo Lanas, Fernando Seron, Pamela Lopez-Jaramillo, Patricio Camacho López, Paul Anthony O’Donnell, Martin J. Rangarajan, Sumathy Teo, Koon Yusuf, Salim 2019-07-02T14:10:11Z 2019-07-02T14:10:11Z 2016-07 10 p. BACKGROUND: Information on actual sodium intake and its relationships with blood pressure (BP) and clinical events in South America is limited. The aim of this cohort study was to assess the relationship of sodium intake with BP, cardiovascular (CV) events, and mortality in South America. METHODS: We studied 17,033 individuals, aged 35–70 years, from 4 South American countries (Argentina, Brazil, Chile, and Colombia). Measures of sodium excretion, estimated from morning fasting urine, were used as a surrogate for daily sodium intake. We measured BP and monitored the composite outcome of death and major CV events. RESULTS: Overall mean sodium excretion was 4.70±1.43g/day. A positive, nonuniform association between sodium and BP was detected, with a significant steeper slope for the relationship at higher sodium excretion levels ( P < 0.001 for interaction). With a median follow-up of 4.7 years, the primary composite outcome (all-cause death, myocardial infarction, stroke, or heart failure) occurred in 568 participants (3.4%). Compared with sodium excretion of 5–6g/day (reference group), participants who excreted >7g/day had increased risks of the primary outcome (odds ratio (OR) 1.73; 95% confidence interval (CI) 1.24 to 2.40; P < 0.001), as well as death from any cause (OR 1.87; 95% CI 1.23 to 2.83; P = 0.003) and major CV disease (OR 1.77; 95% CI 1.12 to 2.81; P = 0.014). Sodium excretion of <3g/day was associated with a statistically nonsignificant increased risk of the primary outcome (OR 1.20; 95% CI 0.86 to 1.65; P = 0.26) and death from any cause (OR 1.25; 95% CI 0.81 to 1.93; P = 0.29), and a significant increased risk of major CV disease (OR 1.50; 95% CI 1.01 to 2.24; P = 0.048), as compared to the reference group. CONCLUSIONS: Our results support a positive, nonuniform association between estimated urinary sodium excretion and BP, and a possible J-shaped pattern of association between sodium excretion over the entire range and clinical outcomes. application/pdf 10.1093/ajh/hpv195 1941-7225 0895-7061 https://repositorio.udes.edu.co/handle/001/3244 eng American Journal of Hypertension Derechos Reservados - American Journal of Hypertension, Ltd, 2016 info:eu-repo/semantics/openAccess Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/ https://watermark.silverchair.com/hpv195.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAjcwggIzBgkqhkiG9w0BBwagggIkMIICIAIBADCCAhkGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMapN2YPJ48mkzfgCJAgEQgIIB6jJzjkzriPNzKmnWWs41qg5WEVyGhNeaZyK-p_29najY8ezksKC4gEqfbQavJsb2AWpbC2m7VkpEyVB-_0hgz9U3ZfHfhkgEIicoEjxpCV4GEsONyJW1NxsCPEJjztBRWVIrQE_ZVdoW0LyPYhLfGJW5IMEHoIr03uhMj2jG2gWbWTiM_SMLAgVmW26Fffh15a7WU_-VMwTO6TXu5kCA1VkGVMZExrik2xx34RBIlcqf-PuWjuccLoppKNxvd1pl3OLf65XZvCPH0HThjEOtfGarcU5UCxnCyo_ptP5J6klDoj2aQNbPKIrJJX2uAafvmn6qUtaKSzo-HdQ4unr2DWoGtmLsXol2qn7sO_58Y-NfdsknP_toAcHHlPNG0iK-rBsAtwWx-d-iaA0ItGtFkfYWdw4s8xB_10eKq5Y-aJTWjIbPSehw24-Fw4sl37COJ_ihwEOuKKStrUZ0nam-3h2EEmnC19AlPg1herPUOEuufBvXafM6u8TwLh3enBFiCGAt8S6yYdJYgTiIDYJO09l-B_EVnJuWdmyGOwu68nNXWvhtF2omRwr8l73ZAUrwrClzcVqzIB8ez3wHdeSETMvZ-KUAKNAggRH-xK1jKJjKn4LzHJFRcP63UlXJEmdslWC7OR2jpMVtt9s Sodium intake Blood pressure Cardiovascular disease Hypertension Mortality Association of urinary sodium excretion with blood pressure and cardiovascular clinical events in 17,033 Latin americans Artículo de revista http://purl.org/coar/resource_type/c_6501 Text info:eu-repo/semantics/article http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion Publication http://purl.org/coar/access_right/c_abf2 http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| institution |
Universidad EIA |
| collection |
d_repositorio.udes.edu.co-DSPACE |
| title |
Association of urinary sodium excretion with blood pressure and cardiovascular clinical events in 17,033 Latin americans |
| spellingShingle |
Association of urinary sodium excretion with blood pressure and cardiovascular clinical events in 17,033 Latin americans Lamelas, Pablo M. Mente, Andrew Diaz, Rafael Orlandini, Andres Avezum, Alvaro Oliveira, Gustavo Lanas, Fernando Seron, Pamela Lopez-Jaramillo, Patricio Camacho López, Paul Anthony O’Donnell, Martin J. Rangarajan, Sumathy Teo, Koon Yusuf, Salim Lamelas, Pablo M. Mente, Andrew Diaz, Rafael Orlandini, Andres Avezum, Alvaro Oliveira, Gustavo Lanas, Fernando Seron, Pamela Lopez-Jaramillo, Patricio Camacho López, Paul Anthony O’Donnell, Martin J. Rangarajan, Sumathy Teo, Koon Yusuf, Salim Sodium intake Blood pressure Cardiovascular disease Hypertension Mortality |
| title_short |
Association of urinary sodium excretion with blood pressure and cardiovascular clinical events in 17,033 Latin americans |
| title_full |
Association of urinary sodium excretion with blood pressure and cardiovascular clinical events in 17,033 Latin americans |
| title_fullStr |
Association of urinary sodium excretion with blood pressure and cardiovascular clinical events in 17,033 Latin americans |
| title_full_unstemmed |
Association of urinary sodium excretion with blood pressure and cardiovascular clinical events in 17,033 Latin americans |
| title_sort |
association of urinary sodium excretion with blood pressure and cardiovascular clinical events in 17,033 latin americans |
| author |
Lamelas, Pablo M. Mente, Andrew Diaz, Rafael Orlandini, Andres Avezum, Alvaro Oliveira, Gustavo Lanas, Fernando Seron, Pamela Lopez-Jaramillo, Patricio Camacho López, Paul Anthony O’Donnell, Martin J. Rangarajan, Sumathy Teo, Koon Yusuf, Salim Lamelas, Pablo M. Mente, Andrew Diaz, Rafael Orlandini, Andres Avezum, Alvaro Oliveira, Gustavo Lanas, Fernando Seron, Pamela Lopez-Jaramillo, Patricio Camacho López, Paul Anthony O’Donnell, Martin J. Rangarajan, Sumathy Teo, Koon Yusuf, Salim |
| author_facet |
Lamelas, Pablo M. Mente, Andrew Diaz, Rafael Orlandini, Andres Avezum, Alvaro Oliveira, Gustavo Lanas, Fernando Seron, Pamela Lopez-Jaramillo, Patricio Camacho López, Paul Anthony O’Donnell, Martin J. Rangarajan, Sumathy Teo, Koon Yusuf, Salim Lamelas, Pablo M. Mente, Andrew Diaz, Rafael Orlandini, Andres Avezum, Alvaro Oliveira, Gustavo Lanas, Fernando Seron, Pamela Lopez-Jaramillo, Patricio Camacho López, Paul Anthony O’Donnell, Martin J. Rangarajan, Sumathy Teo, Koon Yusuf, Salim |
| building |
Repositorio digital |
| topic |
Sodium intake Blood pressure Cardiovascular disease Hypertension Mortality |
| topic_facet |
Sodium intake Blood pressure Cardiovascular disease Hypertension Mortality |
| publishDate |
2016-07 |
| language |
English |
| format |
Artículo de revista |
| description |
BACKGROUND: Information on actual sodium intake and its relationships with blood pressure (BP) and clinical events in South America is limited. The aim of this cohort study was to assess the relationship of sodium intake with BP, cardiovascular (CV) events, and mortality in South America.
METHODS: We studied 17,033 individuals, aged 35–70 years, from 4 South American countries (Argentina, Brazil, Chile, and Colombia). Measures of sodium excretion, estimated from morning fasting urine, were used as a surrogate for daily sodium intake. We measured BP and monitored the composite outcome of death and major CV events.
RESULTS: Overall mean sodium excretion was 4.70±1.43g/day. A positive, nonuniform association between sodium and BP was detected, with a significant steeper slope for the relationship at higher sodium excretion levels ( P < 0.001 for interaction). With a median follow-up of 4.7 years, the primary composite outcome (all-cause death, myocardial infarction, stroke, or heart failure) occurred in 568 participants (3.4%). Compared with sodium excretion of 5–6g/day (reference group), participants who excreted >7g/day had increased risks of the primary outcome (odds ratio (OR) 1.73; 95% confidence interval (CI) 1.24 to 2.40; P < 0.001), as well as death from any cause (OR 1.87; 95% CI 1.23 to 2.83; P = 0.003) and major CV disease (OR 1.77; 95% CI 1.12 to 2.81; P = 0.014). Sodium excretion of <3g/day was associated with a statistically nonsignificant increased risk of the primary outcome (OR 1.20; 95% CI 0.86 to 1.65; P = 0.26) and death from any cause (OR 1.25; 95% CI 0.81 to 1.93; P = 0.29), and a significant increased risk of major CV disease (OR 1.50; 95% CI 1.01 to 2.24; P = 0.048), as compared to the reference group.
CONCLUSIONS: Our results support a positive, nonuniform association between estimated urinary sodium excretion and BP, and a possible J-shaped pattern of association between sodium excretion over the entire range and clinical outcomes.
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| url |
https://repositorio.udes.edu.co/handle/001/3244 |
| url_str_mv |
https://repositorio.udes.edu.co/handle/001/3244 |
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