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Is myopia another clinical manifestation of insulin resistance?

Myopia is a multifactorial visual refraction disease, in which the light rays from distant objects are focused in front of retina, causing blurry vision. Myopic eyes are characterized by an increased corneal curvature and/or ocular axial length. The prevalence of myopia has increased in recent decad...

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Institution:Universidad EIA
Main Authors: Galvis, Virgilio, Lopez-Jaramillo, Patricio, Tello, Alejandro, Castellanos Castellanos, Yuly Andrea, Camacho López, Paul Anthony, Cohen, Daniel Dylan, Gómez Arbeláez, Diego, Merayo Lloves, Jesús
Format: Artículo de revista
Language:English
Published: 2016-02
Subjects:
Myopia
Insulin resistance
Online Access:https://repositorio.udes.edu.co/handle/001/3461
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id oai:repositorio.udes.edu.co:001-3461
recordtype dspace
spelling Galvis, Virgilio
Lopez-Jaramillo, Patricio
Tello, Alejandro
Castellanos Castellanos, Yuly Andrea
Camacho López, Paul Anthony
Cohen, Daniel Dylan
Gómez Arbeláez, Diego
Merayo Lloves, Jesús
2019-07-26T12:43:40Z
2019-07-26T12:43:40Z
2016-02
9 p.
Myopia is a multifactorial visual refraction disease, in which the light rays from distant objects are focused in front of retina, causing blurry vision. Myopic eyes are characterized by an increased corneal curvature and/or ocular axial length. The prevalence of myopia has increased in recent decades, a trend that cannot be attributed exclusively to genetic factors. Low and middle income countries have a higher burden of refractive error, which we propose could be a consequence of a shorter exposure time to a westernized lifestyle, a phenomenon that may also explain the rapid increase in cardiometabolic diseases, such as diabetes, among those populations. We suggest that interactions between genetic, epigenetic and a rapidly changing environment are also involved in myopia onset and progression. Furthermore, we discuss several possible mechanisms by which insulin resistance may promote abnormal ocular growth and myopia to support the hypothesis that insulin resistance and hyperinsulinemia are involved in its pathogenesis, providing a link between trends in myopia and those of cardiometabolic diseases. There is evidence that insulin have direct ocular growth promoting effects as well an indirect effect via the induction of insulin-like growth factors leading to decreases insulin-like growth factor-binding protein, also implicated in ocular growth.
application/pdf
10.1016/j.mehy.2016.02.006
0306-9877
https://repositorio.udes.edu.co/handle/001/3461
eng
Medical Hypotheses
Derechos Reservados - Universidad de Santander, 2016
info:eu-repo/semantics/openAccess
Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
https://creativecommons.org/licenses/by-nc/4.0/
https://www.sciencedirect.com/science/article/abs/pii/S0306987716000487?via%3Dihub
Myopia
Insulin resistance
Is myopia another clinical manifestation of insulin resistance?
Artículo de revista
http://purl.org/coar/resource_type/c_6501
Text
info:eu-repo/semantics/article
http://purl.org/redcol/resource_type/ART
info:eu-repo/semantics/publishedVersion
Publication
http://purl.org/coar/access_right/c_abf2
http://purl.org/coar/version/c_970fb48d4fbd8a85
institution Universidad EIA
collection d_repositorio.udes.edu.co-DSPACE
title Is myopia another clinical manifestation of insulin resistance?
spellingShingle Is myopia another clinical manifestation of insulin resistance?
Galvis, Virgilio
Lopez-Jaramillo, Patricio
Tello, Alejandro
Castellanos Castellanos, Yuly Andrea
Camacho López, Paul Anthony
Cohen, Daniel Dylan
Gómez Arbeláez, Diego
Merayo Lloves, Jesús
Galvis, Virgilio
Lopez-Jaramillo, Patricio
Tello, Alejandro
Castellanos Castellanos, Yuly Andrea
Camacho López, Paul Anthony
Cohen, Daniel Dylan
Gómez Arbeláez, Diego
Merayo Lloves, Jesús
Myopia
Insulin resistance
title_short Is myopia another clinical manifestation of insulin resistance?
title_full Is myopia another clinical manifestation of insulin resistance?
title_fullStr Is myopia another clinical manifestation of insulin resistance?
title_full_unstemmed Is myopia another clinical manifestation of insulin resistance?
title_sort is myopia another clinical manifestation of insulin resistance?
author Galvis, Virgilio
Lopez-Jaramillo, Patricio
Tello, Alejandro
Castellanos Castellanos, Yuly Andrea
Camacho López, Paul Anthony
Cohen, Daniel Dylan
Gómez Arbeláez, Diego
Merayo Lloves, Jesús
Galvis, Virgilio
Lopez-Jaramillo, Patricio
Tello, Alejandro
Castellanos Castellanos, Yuly Andrea
Camacho López, Paul Anthony
Cohen, Daniel Dylan
Gómez Arbeláez, Diego
Merayo Lloves, Jesús
author_facet Galvis, Virgilio
Lopez-Jaramillo, Patricio
Tello, Alejandro
Castellanos Castellanos, Yuly Andrea
Camacho López, Paul Anthony
Cohen, Daniel Dylan
Gómez Arbeláez, Diego
Merayo Lloves, Jesús
Galvis, Virgilio
Lopez-Jaramillo, Patricio
Tello, Alejandro
Castellanos Castellanos, Yuly Andrea
Camacho López, Paul Anthony
Cohen, Daniel Dylan
Gómez Arbeláez, Diego
Merayo Lloves, Jesús
building Repositorio digital
topic Myopia
Insulin resistance
topic_facet Myopia
Insulin resistance
publishDate 2016-02
language English
format Artículo de revista
description Myopia is a multifactorial visual refraction disease, in which the light rays from distant objects are focused in front of retina, causing blurry vision. Myopic eyes are characterized by an increased corneal curvature and/or ocular axial length. The prevalence of myopia has increased in recent decades, a trend that cannot be attributed exclusively to genetic factors. Low and middle income countries have a higher burden of refractive error, which we propose could be a consequence of a shorter exposure time to a westernized lifestyle, a phenomenon that may also explain the rapid increase in cardiometabolic diseases, such as diabetes, among those populations. We suggest that interactions between genetic, epigenetic and a rapidly changing environment are also involved in myopia onset and progression. Furthermore, we discuss several possible mechanisms by which insulin resistance may promote abnormal ocular growth and myopia to support the hypothesis that insulin resistance and hyperinsulinemia are involved in its pathogenesis, providing a link between trends in myopia and those of cardiometabolic diseases. There is evidence that insulin have direct ocular growth promoting effects as well an indirect effect via the induction of insulin-like growth factors leading to decreases insulin-like growth factor-binding protein, also implicated in ocular growth.
issn 0306-9877
url https://repositorio.udes.edu.co/handle/001/3461
url_str_mv https://repositorio.udes.edu.co/handle/001/3461
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score 11.236759