Efecto del remodelado eléctrico auricular en un modelo tridimensional de aurícula humana
The most common cardiac arrhythmias in humans originate in the atrium. Modelling of the atrial activity has become an important tool to analyze arrhythmias such as atrial fibrillation. Experimental studies have shown that atrial fibrillation tends to be perpetual, generating electrophysiological c...
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| Institution: | Universidad EIA |
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| Main Authors: | , , , |
| Format: | Artículo de revista |
| Language: | Español |
| Published: |
Biomédica, Mecatrónica y Mecánica
2014-04-23
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| Subjects: | |
| Online Access: | https://repository.eia.edu.co/handle/11190/453 |
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| Summary: | The most common cardiac arrhythmias in humans originate in the atrium. Modelling of the atrial activity has
become an important tool to analyze arrhythmias such as atrial fibrillation. Experimental studies have shown that atrial fibrillation
tends to be perpetual, generating electrophysiological changes called atrial remodeling. In this study we present a geometrically
realistic three-dimensional (3D) model of human atrium, which incorporates anisotropy, direction of the fibers and conductive
heterogeneity. The effects of remodeling on the ionic currents were applied to an action potential model coupled to the 3D model.
The effects of remodeling on the action potential and its propagation were studied the model reproduced the electrical activity
behavior across the atrial surface. Remodelling induced a reduction in the action potential duration, the effective refractory period
and the conduction velocity. Our results suggest that in the developed 3D model of human atrium is possible to simulate the atrial
electrical activity under physiological conditions and with atrial electrical remodeling
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| Physical Description: | 8 p. |
| ISSN: | ISSN 19099762 |
